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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: July 2026
Volume 11 | Issue 7
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 122
Article Submitted : 25330
Article Published : 9497
Total Authors : 25208
Total Reviewer : 873
Total Countries : 172
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| Paper Title: | Development And Evaluation of Curcumin Loaded In Situ Gel Using N-Acyl Chitosan Derivative for Ulcerative Colitis |
| Authors Name: | Sangam Nimkar , Amruta Phuse , Prasad R. Deshmukh |
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IJRTI_213394
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| Published Paper Id: | IJRTI2606062 |
| Published In: | Volume 11 Issue 6, June-2026 |
| DOI: | |
| Abstract: | This study demonstrates the modification of chitosan into N-Butyryl chitosan, N-Octanoyl chitosan, N-Lauryl chitosan, and N-Palmitoyl chitosan. These modified chitosan’s were synthesized and characterized using FTIR, XRD, and DSC to confirm the successful attachment of the acyl groups at the amino position. The N-acylated chitosan’s were then loaded with the drug curcumin and evaluated for drug loading capacity and swelling index. It was observed that as the carbon chain length increased, solubility also improved, leading to a higher swelling index. The in situ gelling system was compressed into tablets and enterically coated. In vitro release studies were conducted by exposing the gel to both acidic and basic environments. The enteric coating prevented drug release in the acidic environment, while in phosphate buffer at pH 6.8, drug release occurred. These findings suggest that hydrophobically modified acylated chitosan can be effective for achieving sustained drug release, controlled by the acylation modification. |
| Keywords: | Chitosan, N-Acylated chitosan, Curcumin, In situ gel, Sustained release. |
| Cite Article: | "Development And Evaluation of Curcumin Loaded In Situ Gel Using N-Acyl Chitosan Derivative for Ulcerative Colitis", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 6, page no.a604-a615, June-2026, Available :http://www.ijrti.org/papers/IJRTI2606062.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2606062
Registration ID:213394
Published In: Volume 11 Issue 6, June-2026
DOI (Digital Object Identifier):
Page No: a604-a615 Country: Amravati, MAHARASHTRA, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2606062 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2606062 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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