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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Synthesis, characterization and biological effects of a few novel pyrimidine derivatives |
| Authors Name: | Ashok Nagore , Sunita Gupta |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_212452
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| Published Paper Id: | IJRTI2605130 |
| Published In: | Volume 11 Issue 5, May-2026 |
| DOI: | |
| Abstract: | Pyrimidine and its derivatives are crucial in the domains of pharmaceuticals and agricultural chemicals. In recent decades, numerous pharmacological studies have been conducted on Pyrimidine and its derivatives. However, further research is essential to address the need for biological compounds. “Chalcone is an aromatic compound that serves as the central core for various biological compounds. Chalcone is produced through an aldol condensation of 4-methoxy acetophenone with m-phenoxy benzaldehydes, utilizing a catalyst that is subsequently treated with thiourea to yield Pyrimidine. The Pyrimidine, when treated with substituted N-1,3-benzothiazole-2-yl-2-chloro amide, results in a compound”. Elemental analysis, IR, 1H-NMR, 13C-NMR), M.P. and TLC using silica gel G are employed to assess the purity of the compounds. All synthesized compounds were evaluated against four distinct strains, specifically two Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and were compared with standard antibiotics such as ampicillin, chloramphenicol, ciprofloxacin and norfloxacin. Additionally, all synthesized compounds were tested against Candida albicans and Aspergillus niger, with analyses conducted alongside standard antifungal agents nystatin and griseofulvin. This paper emphasizes the reactions, synthesis, spectral analysis, and microbial activities of pyrimidine-based benzothiazole derivatives. The methodology presented demonstrates superior results compared to previously published literature. Several of the compounds exhibited significant efficacy as antimicrobial and antifungal agents. |
| Keywords: | Antimicrobial activity; Benzothiazole; Pyrimidine |
| Cite Article: | "Synthesis, characterization and biological effects of a few novel pyrimidine derivatives", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 5, page no.b242-b251, May-2026, Available :http://www.ijrti.org/papers/IJRTI2605130.pdf |
| Downloads: | 00085 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2605130
Registration ID:212452
Published In: Volume 11 Issue 5, May-2026
DOI (Digital Object Identifier):
Page No: b242-b251 Country: Rewa, M.P., India Research Area: Chemistry Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2605130 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2605130 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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