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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: February 2026
Volume 11 | Issue 2
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Impact Factor : 8.14
Issue per Year : 12
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Issue Published : 117
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| Paper Title: | Spectrum of Sinonasal Fungal Lesions: A Cross Sectional Histopathological Study At a Tertiary Care Hospital |
| Authors Name: | Dr. K NAZMA , Dr. Naval Kishore , Dr. M.Mamatha , Dr.R P Sushma kumari |
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IJRTI_208697
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| Published Paper Id: | IJRTI2601041 |
| Published In: | Volume 11 Issue 1, January-2026 |
| DOI: | |
| Abstract: | Background: Sinonasal fungal infections have emerged as an important clinical entity worldwide, with a marked rise in incidence following the COVID-19 pandemic. These lesions range from non-invasive allergic forms to rapidly progressive invasive fungal sinusitis, particularly in immunocompromised individuals. Histopathology remains the diagnostic gold standard. Aim: To evaluate the histopathological spectrum of fungal lesions in the sinonasal tract and correlate findings with clinical and demographic features. Materials and Methods: A cross-sectional study of 117 cases was conducted over two years in a tertiary care center. Biopsy specimens from clinically suspected fungal sinusitis were processed, stained with H&E, and supplemented with PAS and GMS wherever required. Data regarding demographics, symptoms, anatomical site, fungal subtype, necrosis, granulomas, eosinophils, bone invasion, and KOH positivity were analyzed using SPSS v27. Results: The mean patient age was 42.28 years; males constituted 54.7%. The most common diagnosis was Allergic Fungal Rhinosinusitis (AFRS) (29.91%), followed by Acute Invasive Fungal Sinusitis (AIFS) (25.64%) and fungal ball (16.24%). Eosinophilic infiltration was highest in AFRS (74.29%), whereas granulomas predominated in Chronic Granulomatous Fungal Sinusitis (82.35%). Bone invasion (60%) and necrosis were most frequent in AIFS. Maxillary sinuses were the most commonly involved sites bilaterally. KOH positivity varied across groups (15.79–47.06%) but did not show statistical significance. Conclusion: Sinonasal fungal lesions show a wide histopathological spectrum with distinct immune and tissue response patterns. Allergic fungal rhinosinusitis remains the most common non-invasive subtype, while Acute invasive fungal sinusitis exhibits aggressive features such as necrosis and bone invasion. Early histopathological diagnosis remains crucial for timely intervention. |
| Keywords: | Fungal rhinosinusitis, invasive fungal sinusitis, mucormycosis, allergic fungal sinusitis, histopathology, sinus infections. |
| Cite Article: | "Spectrum of Sinonasal Fungal Lesions: A Cross Sectional Histopathological Study At a Tertiary Care Hospital ", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.11, Issue 1, page no.a318-a324, January-2026, Available :http://www.ijrti.org/papers/IJRTI2601041.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2601041
Registration ID:208697
Published In: Volume 11 Issue 1, January-2026
DOI (Digital Object Identifier):
Page No: a318-a324 Country: Kadapa, Andhra pradesh, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2601041 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2601041 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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