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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Formulation and Evaluation of Saxagliptin Trandermal Patches Of Anti Diabetic DrugsFormulation and Evaluation of Saxagliptin Trandermal Patches Of Anti Diabetic Drugs |
| Authors Name: | Umesh Kumar chaurasiya , Dipti Patel |
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| Author Reg. ID: |
IJRTI_206967
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| Published Paper Id: | IJRTI2510144 |
| Published In: | Volume 10 Issue 10, October-2025 |
| DOI: | |
| Abstract: | The transdermal drug delivery systems were developed to overcome the limitations associated with oral administration and to mimic the effects of intravenous infusion. The solubility of poorly soluble anti-diabetic drugs was enhanced by preparing solid dispersion using beta cyclodextrin as a carrier in the ratio of 1:2. The solid dispersions were evaluated by solubility study, scanning electron microscopy and X-ray diffraction studies which indicated the conversion of drug into amorphous form. The permeability of saxagliptin was enhanced by employing 4% sodium lauryl sulphate by co- surfactant method. The above mentioned physically modified drugs were formulated as transdermal delivery systems using hydroxy propyl methyl cellulose, ethyl cellulose and chitosan as rate controlling polymers. The formulated transdermal drug delivery systems were evaluated for physico-chemical properties and in vitro diffusion study and in vivo studies. Based on the evaluation criteria S4 (saxagliptin) which were on par with the aim and objective of the present investigation were optimized. Compatibility studies indicated that there was no chemical interaction between the drugs and polymers employed in the formulation. It was found that there was significant reduction in the blood glucose levels on transdermal administration for a prolonged period of time without hypoglycemic effect. |
| Keywords: | transdermal,diffusion,administration,saxagliptin |
| Cite Article: | "Formulation and Evaluation of Saxagliptin Trandermal Patches Of Anti Diabetic DrugsFormulation and Evaluation of Saxagliptin Trandermal Patches Of Anti Diabetic Drugs", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 10, page no.b354-b366, October-2025, Available :http://www.ijrti.org/papers/IJRTI2510144.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2510144
Registration ID:206967
Published In: Volume 10 Issue 10, October-2025
DOI (Digital Object Identifier):
Page No: b354-b366 Country: Chhatarpur, Madhya Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2510144 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2510144 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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