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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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| Paper Title: | In-vivo Anti-hepatotoxic Pharmacological Investigations of Coccinia indica (Ivy-Gourd) in Albino Wistar Rats |
| Authors Name: | Vikash Kumar , Amrita Singh , Sonia Bhatt , Ritesh Rai , Bhanu P. S. Sagar |
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IJRTI_188451
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| Published Paper Id: | IJRTI2311028 |
| Published In: | Volume 8 Issue 11, November-2023 |
| DOI: | |
| Abstract: | This research work was performed on Coccinia indica Wight & Arn (Kundru; Ivy-gourd; Cucurbitaceae) for antioxidant and anti-hepatotoxic activity against paracetamol in wistar rats. Kundru contains indicated phenolics, flavanoids, glycosides, terpenoids and phytosterols as SPMs. Extractive values in leaves (ASEV:8.6%; WSEV: 24.8%; AIAV: 1.783%; WSAV: 8.93%) and fruits (ASEV:8.8%; WSEV: 25.20%; AIAV: 1.834%; WSAV: 9.68%) were calculated. Practical yield were 2.4% (leaves) and 2.72% (fruits) and Quercetin isolated (Rf value 0.46 and λmax 370 nm) from MECIL and MECIF. In anti-hepatotoxic activity, PCM induced hepatoxicity by glutathione depletion, necrosis of hepatocytes, elevated hepatic biochemical parameters with centilobular necrosis. MECIF and MECIL extract produced remarkable anti- hepatotoxic activity with significant alleviation of LFTs and reddish coloration, normal anatomical architecture. Anti-hepatotoxic effects were comparatively lesser then standard (Silymarin). and mechanism include anti-inflammatory (inhibition of phopholipase A2), membrane stabilization, anti-oxidant, glutathione restoration and enhanced RNA synthesis. |
| Keywords: | Anti-hepatotoxic, Coccinia indica, Drug-induced heptotoxicity (DIH), Kundru, Quercetin, physiochemical, extractive value, liver function tests (LFTs), retro-orbital sinus, secondary plant metabolites (SPMs), silymarin |
| Cite Article: | "In-vivo Anti-hepatotoxic Pharmacological Investigations of Coccinia indica (Ivy-Gourd) in Albino Wistar Rats", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 11, page no.198 - 209, November-2023, Available :http://www.ijrti.org/papers/IJRTI2311028.pdf |
| Downloads: | 000205152 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2311028
Registration ID:188451
Published In: Volume 8 Issue 11, November-2023
DOI (Digital Object Identifier):
Page No: 198 - 209 Country: -, -, India Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2311028 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2311028 |
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ISSN: 2456-3315
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