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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 113
Article Submitted : 18245
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Total Authors : 20583
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| Paper Title: | Using in-silico screening analysis, Elettaria cardamomum is investigated as a medicinal plant in an effort to find novel potential inhibitors for cardiovascular diseases (CVD) in the form of its phytoconstituents sabinene, α-terpineol, and α-pinene. |
| Authors Name: | Sudhanshu Kumar Jha , Sneep Kumar Chaturvedi , Rupali Verma , Jeevika Raina , Lokesh Sharma |
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IJRTI_185489
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| Published Paper Id: | IJRTI2303036 |
| Published In: | Volume 8 Issue 3, March-2023 |
| DOI: | |
| Abstract: | Cardiovascular disease (CVD) is an umbrella term for a number of linked pathologies, commonly defined as coronary heart disease (CHD), cerebrovascular disease, peripheral arterial disease, rheumatic and congenital heart diseases and venous thromboembolism. Globally CVD accounts for 31% of mortality, the majority of this in the form of CHD and cerebrovascular accident. The current work used molecular docking techniques to evaluate several physiologically active chemicals found in medicinal plants as possible inhibitors. The Maestro 12.8 did the Docking study contrasting the anti-cardiac medication Quinapril as a standard drug with the phytoconstituents found in Elettaria cardamomum capsules contains Sabinene, α -terpineol, α –pinene. The outcomes show the potency of this screening approach, which can hasten the development of novel drugs to treat emerging infectious diseases and disorders. Use of Cardiac receptor having PDB id (1LXF) and the when compared to the anticardiac medicine Quinapril, whose docking score was -5.647, the phytoconstituents screening chemicals extracted from the medicinal plant Elettaria cardamomum, such as Sabinene (-6.715), α –terpineol (-6.161), α –pinene (-6.078) were more effective than standard anticardiac medication quinapril whose docking score is (-5.647). The docking results reveal that phytoconstituents found in Elettaria cardamomum plants have a great deal of potency against cardiovascular diseases condition and can be utilised to inhibit various cardiovascular diseases, making them an essential source for new anticardiac medications in the future that target cardiovascualar diseases. |
| Keywords: | Cardiovascular diseases, Quinapril, Sabinene, α -terpineol, α -pinene, Docking score, In-silico screening. |
| Cite Article: | "Using in-silico screening analysis, Elettaria cardamomum is investigated as a medicinal plant in an effort to find novel potential inhibitors for cardiovascular diseases (CVD) in the form of its phytoconstituents sabinene, α-terpineol, and α-pinene.", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 3, page no.218 - 225, March-2023, Available :http://www.ijrti.org/papers/IJRTI2303036.pdf |
| Downloads: | 000205110 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2303036
Registration ID:185489
Published In: Volume 8 Issue 3, March-2023
DOI (Digital Object Identifier):
Page No: 218 - 225 Country: Dadri, Noida, Uttar Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2303036 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2303036 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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