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Alginate, a linear unbranched Hetero polysaccharide, is composed of (1–4)-linked β D – mannuronate (M) and α-L-guluronate (G). The relative amount and distribution of these two residues vary with species and growth conditions. It occurs as white to yellowish brown filamentous , grainy granular or powder forms. Alginate lyase can degrade alginate by cleaving the glycosidic bond through a β-elimination reaction. Alginate lyases possess different substrate specificities
In general, the microorganism that grow on alginate use extracellular alginate lyases to degrade alginate and then transport the degraded product into cytoplasm to assimilate them via-cellular metabolism .Alginate lyase is a member of the polysaccharide lyases (PLs, EC422).
Alginate is naturally occurring anionic polymer typically obtained from brown seaweed ,and has been extensively investigated and used for many biomedical applications ,due to its biocompatibility ,low toxicity ,relatively low cost .Alginate is produced by brown algae and some bacteria belonging to the genera Azotobacter , as well as several species of Pseudomonas, and is also found in acetylated and non-acetylated forms. algLs are produced by a number of microorganisms, including marine algae , marine molluscs , fungi, bacteria such as Bacillus circulans and Gram-negative bacteria like Azotobacter vinelandii , Klebsiella aerogenes , K. pneumonia, Pseudomonas maltophilia .The alginate lyase can be used as an adjuvant therapeutic agent for the treatment of infection by mucoid strains of P.aeruginosa. algL has also a potential application for enhancing the bacteriocidal effects of antibiotics against mucoid P.aeruginosa in biofilms.
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Cite Article:
"ISOLATION AND OPTIMISATION OF ALGINATE LYASE PRODUCING MICROORGANISM FROM RHIZOSPHERE AND SURFACE SOIL", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 8, page no.567 - 574, August-2022, Available :http://www.ijrti.org/papers/IJRTI2208096.pdf
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator