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Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blind
ness, where early detection is essential for preventing vision loss. However, existing
automated approaches often suffer from limitations such as loss of spatial relation
ships, lack of interpretability, and high computational complexity. To address these
challenges, this paper proposes a novel multi-stage glaucoma detection framework that
integrates Capsule Network (CapsNet)-based deep feature extraction with clinically
relevant handcrafted features, unified through an Extreme Learning Machine (ELM)
classifier. The preprocessing stage enhances retinal structures using red-channel extrac
tion, contrast-limited adaptive histogram equalization (CLAHE), filtering, and normal
ization. CapsNet effectively preserves spatial dependencies between optic disc and cup
regions, while handcrafted features including GLCM texture, color statistics, entropy,
and edge information incorporate domain-specific knowledge. The fused feature rep
resentation is efficiently classified using ELM, enabling fast and accurate prediction.
Additionally, SHAP-based explainability is employed to provide both global and local
interpretability of model decisions. Experimental results on the ORIGA dataset demon
strate that the proposed framework achieves superior performance, with an accuracy
of 91.50%, sensitivity of 90.00%, specificity of 91.44%, and AUC of 0.9065, outperform
ing conventional machine learning and deep learning models. These results highlight
the effectiveness of combining deep and handcrafted features with an efficient classifier.
The proposed approach offers a reliable, interpretable, and computationally efficient
solution for automated glaucoma screening in clinical applications.
Keywords:
Cite Article:
"A Multi-Stage Transformer-U-Net and ELM Framework for Early Glaucoma Detection", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 7, page no.a29-a46, July-2026, Available :http://www.ijrti.org/papers/IJRTI2607004.pdf
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator