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The study focused on developing and evaluating fast-dissolving ibuprofen tablets to address its limitations, including poor solubility, a short half-life, and gastric irritation. Super disintegrants were incorporated to enhance drug dissolution and absorption. Two approaches were used: first, varying concentrations of sodium starch glycolate (2.5–6.25%) were tested, and second, different super disintegrants (sodium starch glycolate, croscarmellose sodium, and crospovidone ) were compared at a fixed concentration. Tablets were prepared using direct compression. Results showed that increasing the concentration of sodium starch glycolate improved drug release, with 6.25% giving the best performance. Among the super disintegrants, crospovidone demonstrated the most effective and rapid disintegration, leading to enhanced dissolution.
"Formulation And Evaluation Of Fast Dissolving Tablet: Ibuprofen ", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 5, page no.a180-a199, May-2026, Available :http://www.ijrti.org/papers/IJRTI2605022.pdf
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator