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Orodispersible films (ODFs) represent a cutting-edge advancement in oral solid dosage forms, primarily valued for their versatility and ease of administration. Designed to disintegrate rapidly upon contact with saliva, these films eliminate the need for chewing or water. A significant therapeutic advantage of ODFs is their ability to bypass first-pass metabolism, which enhances the drug's bioavailability, speeds up the onset of action, and allows for lower dosages. Furthermore, they mitigate choking risks, making them safer for many patients.
Manufacturing typically involves solvent or semi-solid casting techniques, which facilitate the incorporation of taste-masking agents. Solvent casting is particularly preferred as it ensures superior thickness uniformity, a high-quality glossy finish, and robust physical characteristics. Assessing the quality of these films involves analyzing critical parameters such as thickness, folding endurance, disintegration rate, and dissolution profiles. This overview details the various formulation strategies and essential evaluation criteria for mouth-dissolving films
Keywords:
Bioavailability, fast disintegration, onset of action, orodispersible film, solvent casting,
Cite Article:
"An Innovative and Effective Drug Delivery System : Mouth Dissolving Film", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 4, page no.b452-b462, April-2026, Available :http://www.ijrti.org/papers/IJRTI2604198.pdf
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ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator