 |
International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.14 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
|
Issue: April 2026
Volume 11 | Issue 4
Review Result and Publication of Paper within : 2-3 days
Click Here For more DetailsFor Authors
Forms / Download
Published Issue Details
Editorial Board
Other IMP Links
Facts & Figure
Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 119
Article Submitted : 23355
Article Published : 9033
Total Authors : 23952
Total Reviewer : 831
Total Countries : 162
Indexing Partner
Licence
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
Published Paper Details
|
|
| Paper Title: | Application of Click Chemistry in Drug Discovery and Development |
| Authors Name: | Narayan Wamanrao Choudhari |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_211192
|
| Published Paper Id: | IJRTI2604071 |
| Published In: | Volume 11 Issue 4, April-2026 |
| DOI: | |
| Abstract: | The concept Click chemistry was introduced by K. Barry Sharpless in 2001 and honored with the 2022 Nobel Prize in Chemistry, comprises a class of highly efficient, selective, and bioorthogonal reactions that facilitate the rapid construction of complex molecular architectures under mild conditions. This review examines the role of click chemistry throughout the drug discovery and development pipeline, ranging from fragment-based lead identification and combinatorial library generation to targeted drug delivery, fabrication of antibody–drug conjugates (ADCs), prodrug activation, chemical proteomics, and radiopharmaceutical applications. The mechanistic aspects of key click reactions—including copper-catalyzed azide–alkyne cycloaddition (CuAAC), strain-promoted azide–alkyne cycloaddition (SPAAC), tetrazine ligation, and thiol–ene reactions—are discussed, along with a critical assessment of their benefits, limitations, and progress toward clinical translation. Additionally, emerging areas such as DNA-encoded chemical libraries, covalent drug discovery, and in vivo bioorthogonal chemistry are highlighted. |
| Keywords: | Click chemistry, bioorthogonal chemistry, azide-alkyne cycloaddition, antibody-drug conjugates, drug delivery, chemical proteomics, fragment-based drug discovery |
| Cite Article: | "Application of Click Chemistry in Drug Discovery and Development", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.11, Issue 4, page no.a526-a528, April-2026, Available :http://www.ijrti.org/papers/IJRTI2604071.pdf |
| Downloads: | 00080 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2604071
Registration ID:211192
Published In: Volume 11 Issue 4, April-2026
DOI (Digital Object Identifier):
Page No: a526-a528 Country: Parbhani, Maharashtra, India Research Area: Chemistry Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2604071 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2604071 |
| Share Article: | |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijrti.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
ISSN Details
 |
 |
|
ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
DOI (A digital object identifier)
| Providing A digital object identifier by DOI.ONE How to Get DOI? |
Conference
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Important Details
Join RMS/Earn 300
WhatsApp
Click Here
Click Here
Indexing Partner |
|||
| Copyright © 2026 - All Rights Reserved - IJRTI | |||