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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Issue: February 2026
Volume 11 | Issue 2
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 117
Article Submitted : 21318
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Total Authors : 22301
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| Paper Title: | Osteopontin Immunohistochemical Expression in Premalignant Breast Lesions: A Cross-Sectional Study from a Tertiary Care Center in South India |
| Authors Name: | Dr. Uppala Jhansi , Dr. R. Nagarjuna Chary , Dr. Naval Kishore Bajaj , Dr. K. Swarajya Kumari |
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IJRTI_208300
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| Published Paper Id: | IJRTI2601040 |
| Published In: | Volume 11 Issue 1, January-2026 |
| DOI: | |
| Abstract: | Abstract Background: Premalignant breast lesions including atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) represent pivotal stages in breast carcinogenesis where reliable biomarkers for progression risk assessment remain scarce. Osteopontin (OPN), a multifunctional glycoprotein implicated in tumor invasion and angiogenesis, demonstrates progressive upregulation across neoplastic progression. Methods: This cross-sectional observational study evaluated 94 patients presenting with breast lumps at Osmania General Hospital, Hyderabad (2023-2025). Following institutional ethics approval and informed consent, excisional/core biopsies from clinically benign lesions underwent hematoxylin-eosin (H&E) evaluation per WHO 2019 criteria and OPN immunohistochemistry (IHC). Semi-quantitative H-score (intensity × percentage positivity, range 0-300) assessed cytoplasmic OPN expression. Chi-square/Fisher's exact tests analyzed associations (p<0.05 significant); receiver operating characteristic (ROC) curves determined discriminatory performance using SPSS v25. Results: Mean patient age was 32.18±6.78 years (range 20-44). Fibrocystic disease predominated (53.2%, n=50), followed by ADH (19.1%, n=18) and DCIS (16%, n=15). OPN positivity occurred at 29.8% (n=28), highest in DCIS (73.3%) versus fibrocystic disease (18%). Significant correlations emerged with histopathological diagnosis (p=0.0015), BIRADS category (p=0.0047), and >50% positive cells (p=0.00001). Median H-score was 74 (IQR 38.5-118, range 12-267); ROC analysis yielded AUC 0.468 (cutoff 31: sensitivity 88.9%, specificity 22.4%). Progressive intensification characterized OPN expression from benign to premalignant lesions. Conclusions: OPN demonstrates statistically significant upregulation correlating with premalignant progression, supporting its adjunctive role in risk stratification despite modest specificity. Multicentric prospective validation could establish clinical thresholds for surveillance intensification. |
| Keywords: | keywords Osteopontin, premalignant breast lesions, ductal carcinoma in situ, atypical ductal hyperplasia, immunohistochemistry, H-score. |
| Cite Article: | "Osteopontin Immunohistochemical Expression in Premalignant Breast Lesions: A Cross-Sectional Study from a Tertiary Care Center in South India", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.11, Issue 1, page no.a309-a317, January-2026, Available :http://www.ijrti.org/papers/IJRTI2601040.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2601040
Registration ID:208300
Published In: Volume 11 Issue 1, January-2026
DOI (Digital Object Identifier):
Page No: a309-a317 Country: Hyderabad , Telangana , India Research Area: Health Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2601040 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2601040 |
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ISSN: 2456-3315
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