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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Berberine HCl and Gallic Acid: A Multi-Targeted Approach for Diabetic Nephropathy Management |
| Authors Name: | Gottimukkala Rakshitha , P. Roshan Ali , V. V. Rajesham , Kavirayani Naga Lakshmi Shivani , S Sravanthi |
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IJRTI_206468
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| Published Paper Id: | IJRTI2509129 |
| Published In: | Volume 10 Issue 9, September-2025 |
| DOI: | |
| Abstract: | Diabetes-associated nephropathy (DN), an advancing consequence of diabetes, is the primary trigger for end-stage renal disease (ESRD) globally. Despite advances in traditional medicines like ACE-inhibiting drugs & ARBs, their limited effectiveness highlights the need for novel therapeutic techniques. This study investigates the combined effect of a combination that is berberine HCl and gallic acid, 2 natural substances with complimentary modes of action, in slowing DN development. By activating AMPK and inhibiting NF-κB, the isoquinoline alkaloid berberine HCl decreases oxidative stress, increases insulin sensitivity, and lowers inflammation. Gallic acid is a polyphenolic molecule that scavenges free radicals, modulates inflammatory mediators, and regulates epigenetics to provide strong antioxidant and anti-inflammatory actions. Berberine HCl and gallic acid work in concert to improve nephroprotection by simultaneously addressing inflammation, oxidative stress, and fibrosis brought on by hyperglycemia, according to preclinical research. This study examines the pharmacological characteristics, molecular processes, and therapeutic effectiveness of both drugs, with an emphasis on the combined effects in diabetes animals. We also review current clinical studies, translational hurdles, and future research goals for optimizing this co-treatment strategy. This study demonstrates the potential of gallic acid and berberine HCl as a new, multi-targeted strategy for DN management by combining pre-clinical data and clinical observations. We conclude with clinical practice suggestions, emphasizing the need for more study to establish the synergistic therapy's safety, effectiveness, and long-term advantages. |
| Keywords: | Diabetic Nephropathy, Berberine HCl, Gallic Acid, Synergistic Effect, Oxidative Stress, Renal Protection, Natural Compounds |
| Cite Article: | "Berberine HCl and Gallic Acid: A Multi-Targeted Approach for Diabetic Nephropathy Management", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 9, page no.b211-b244, September-2025, Available :http://www.ijrti.org/papers/IJRTI2509129.pdf |
| Downloads: | 000287 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2509129
Registration ID:206468
Published In: Volume 10 Issue 9, September-2025
DOI (Digital Object Identifier):
Page No: b211-b244 Country: Hyderabad, Telangana, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2509129 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2509129 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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