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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Development and Characterization of Fluconazole-Loaded Nanosuspension Systems for Improved Solubility, Dissolution Rate, and Oral Bioavailability |
| Authors Name: | Yuvraj Pravin Lokhande , Dr. Sadhana Shahi , Suraj Khatavkar , Kedar Shinde |
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IJRTI_204888
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| Published Paper Id: | IJRTI2506150 |
| Published In: | Volume 10 Issue 6, June-2025 |
| DOI: | |
| Abstract: | A type of drug delivery systems based on nanoparticles called nanosuspension has shown promise in addressing the drawbacks of conventional drug delivery techniques, especially for hydrophobic medications. Very low bioavailability is one of the main issues with poorly soluble medications. For medications like itraconazole, fluconazole, simvastatin, and carbamazepine that are poorly soluble in both aqueous and nonaqueous conditions and fall under BCS class II according to the biopharmaceutical categorization system, the issue is even more complicated. An appealing and potential substitute for these issues is formulation as nanosuspension. The pure, weakly water-soluble medication, free of any matrix ingredient, is suspended in dispersion as nanosuspension. Nanosuspension is easy to prepare and works with any medication that is insoluble in water. A nanosuspension increases medication safety and efficacy by changing the pharmacokinetics of the medicine in addition to resolving issues with low solubility and bioavailability. Nanosuspension technique can increase the medications' stability and bioavailability. Nanosuspension is easy to prepare and works with any medication that is aqueously insoluble. Wet mills, high pressure homogenizers, melt emulsification, emulsion-solvent evaporation, and super critical fluid processes are used to create nanosuspensions. Oral, parenteral, pulmonary, and ophthalmic methods can all be used to administer nanosuspensions. Incorporating nanosuspensions into mucoadhesive hydrogels and ocular inserts can also be utilized for targeted medication delivery. This review article explains the nanosuspension's characterisation, applications, and preparation techniques. |
| Keywords: | Nanosuspensions, Solubility enhancement, High pressure homogenization, Media milling, Drug delivery |
| Cite Article: | "Development and Characterization of Fluconazole-Loaded Nanosuspension Systems for Improved Solubility, Dissolution Rate, and Oral Bioavailability", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 6, page no.b396-b412, June-2025, Available :http://www.ijrti.org/papers/IJRTI2506150.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2506150
Registration ID:204888
Published In: Volume 10 Issue 6, June-2025
DOI (Digital Object Identifier):
Page No: b396-b412 Country: KARAD, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2506150 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2506150 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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