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Approximately 40% of new chemical entities suffer from poor aqueous solubility, limiting their oral bioavailability. Self-emulsifying drug delivery systems (SEDDS), comprising oils, surfactants, and co-solvents, offer an effective strategy to enhance the absorption of hydrophobic drugs by applying QbD, While conventional SEDDS are typically in liquid form, they can pose stability and handling challenges. To address this, solid SEDDS (S-SEDDS) have been developed by solidifying liquid formulations into powders, offering improved stability and patient compliance. These systems form fine, stable oil-in-water emulsions in the gastrointestinal tract, enhancing drug solubilization and absorption.
Keywords:
Drug Selection Criteria, Thermodynamic stability, pH Measurement, In vitro diffusion, Drug Content, In-vitro Dissolution, Solubility study.
Cite Article:
"Design and Development of Self Emulsifying Drug Delivery System by using QbD ", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 6, page no.b241-b260, June-2025, Available :http://www.ijrti.org/papers/IJRTI2506132.pdf
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ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator