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This study centers around the development and assessment of an emulgel for the topical application of thiocolchicoside, a muscle relaxant that has low oral absorption and is known to cause gastrointestinal side effects. The goal was to create a reliable, efficient and patient-friendly topical solution that improves skin absorption and delivers targeted treatment. Emulgel formulations were prepared using various concentrations of gelling agents, emulsifying agents and oils and were evaluated for physical appearance, pH, viscosity, spreadability, extrudability, drug content, and in vitro drug release. The improved formulation showed promising physical characteristics and maintained drug release for a duration of 8 hours. The formulation demonstrated excellent stability and compatibility with the skin suggesting its potential as a suitable alternative for the topical application of thiocolchicoside in the treatment of musculoskeletal conditions.
Keywords:
Thiocolchicoside, Emulgel, Topical delivery, Skin permeation, In vitro release.
Cite Article:
"formulation and evaluation of emulgel for topical delivery of drug", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 5, page no.c723-c733, May-2025, Available :http://www.ijrti.org/papers/IJRTI2505285.pdf
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000384
ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator