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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | In-vitro Comparative Study of Synthetic (Limcee Tablet) and Natural (Himalaya Amalaki Tablet) Vitamin C Tablets |
| Authors Name: | Snehal Diliprao Nangare , P.S. Kandalkar , R.S. Mohan |
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IJRTI_204020
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| Published Paper Id: | IJRTI2505198 |
| Published In: | Volume 10 Issue 5, May-2025 |
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| Abstract: | Abstract The present study was undertaken to conduct an in-vitro comparative evaluation of synthetic and natural Vitamin C tablet formulations by analyzing their organoleptic characteristics, solubility, pH, dissolution behavior, and short-term physical stability. For this purpose, two commercially available formulations were selected: Limcee 500 mg tablet as the synthetic Vitamin C formulation and Himalaya Amalaki tablet as the natural herbal Vitamin C source. The organoleptic evaluation involved assessment of the color, odor, taste, and physical appearance of both tablets. A solubility test was performed by dissolving each formulation in distilled water and recording the time taken for complete dissolution. The pH of the resulting solutions was measured using a calibrated digital pH meter to assess the relative acidity of both formulations. An in-vitro dissolution study was conducted by withdrawing samples at specific time intervals (5, 10, 15, and 30 minutes) and determining the percentage drugrelease using aUV-Visible spectrophotometer at 243 nm. Additionally, a short-term stability study was carried out by observing both formulations for physical changes such as color and clarity over a 24-hour period at room temperature. The results indicated that the Limcee tablet demonstrated a faster dissolution rate, achieving 90% drug release within 15 minutes and 100% at 30 minutes. Its pH was recorded at 3.8, reflecting moderate acidity. In contrast, the Himalaya Amalaki tablet exhibited a controlled and gradual release profile, reaching 85% dissolution at 15 minutes and 95% at 30 minutes, with a pH of 3.6, making it comparatively less acidic and potentially more gastric-friendly. Organoleptic evaluation showed significant differences in appearance and taste between the two formulations, with the synthetic Limcee tablet displaying a typical pharmaceutical appearance and the Himalaya Amalaki tablet reflecting its natural, herbal origin. In the stability study, both tablets remained stable for 12 hours, while minor color darkening was observed in the Himalaya Amalaki tablet after 24 hours due to the presence of natural phytoconstituents. The comparative analysis confirmed that synthetic Vitamin C formulations like Limcee offer rapid bioavailability and consistent dosing, while natural Vitamin C formulations such as Himalaya Amalaki tablet provide additional health benefits from herbal antioxidants, better gastric tolerance, and enhanced stability. The study highlights the importance of selecting an appropriate formulation based on clinical objectives, patient preferences, affordability, and therapeutic outcomes. |
| Keywords: | Keywords: Vitamin C, Limcee tablet, Himalaya Amalaki tablet, In-vitro evaluation, Dissolution study, Solubility test, pH measurement, Stability study, Natural vs Synthetic formulation, Herbal antioxidants, Comparative analysis. |
| Cite Article: | "In-vitro Comparative Study of Synthetic (Limcee Tablet) and Natural (Himalaya Amalaki Tablet) Vitamin C Tablets", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.10, Issue 5, page no.b864-b874, May-2025, Available :http://www.ijrti.org/papers/IJRTI2505198.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2505198
Registration ID:204020
Published In: Volume 10 Issue 5, May-2025
DOI (Digital Object Identifier):
Page No: b864-b874 Country: Chh.Sambhaji Nagar, Maharashtra , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2505198 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2505198 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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