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Hot-melt extrusion (HME) is a solvent-free, continuous, and efficient process for producing various pharmaceutical dosage forms. HME has gained significant attention in the pharmaceutical industry due to its ability to enhance the solubility and bioavailability of poorly soluble drugs, develop abuse-deterrent formulations, and create customized drug delivery systems. This review aims to provide an overview of the recent advancements and applications of HME in the pharmaceutical field. The review discusses the fundamental principles of HME, including the equipment, process parameters, and commonly used materials. It highlights the advantages of HME over conventional techniques, such as improved drug dissolution, enhanced stability, and reduced manufacturing steps. The review also explores the various applications of HME in pharmaceutical development, including: Solid, Abuse-deterrent drug delivery, gastro retentive drug, taste masking of bitter APIs using polymeric carriers, preparation of films for buccal, transdermal, and wound healing applications and veterinary medicine, such as the development of long-acting injectable formulations and taste-masked dosage forms for animals. The review highlights the recent advancements and applications of HME in the pharmaceutical field, demonstrating its potential to improve drug delivery and patient outcomes.
Keywords:
Hot Melt Extrusion, Continuous Manufacturing, Form Conversion. Veterinary Medicine.
Cite Article:
"Hot Melt Extrusion: A Review of Recent Developments.", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 7, page no.256 - 276, July-2024, Available :http://www.ijrti.org/papers/IJRTI2407027.pdf
Downloads:
000204756
ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator