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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Volume 10 | Issue 9
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 112
Article Submitted : 17346
Article Published : 7552
Total Authors : 20065
Total Reviewer : 733
Total Countries : 133
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| Paper Title: | FORMULATION AND EVALUATION OF GASTRORETENTIVE (FLOATING) DRUG DELIVERY SYSTEM OF ANTI- METABOLITE DRUG. |
| Authors Name: | Monali T. Dhapate , Manoj Shirbhate |
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IJRTI_190116
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| Published Paper Id: | IJRTI2407016 |
| Published In: | Volume 9 Issue 7, July-2024 |
| DOI: | |
| Abstract: | A multiple unit oral floating drug delivery system of famotidine was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability. Drug and polymer compatibility was studied by subjecting physical mixtures of drug and polymers to differential scanning calorimetry. DSC study decreases in sharpness and enthalpy of drug characteristic peak indicate the drug goes in to microspheres and reduces its crystalline as well as formulations goes in to amorphous state which indicates glass transition temperature. XRD graph of pure 5-Fluorouracil drug. It is concluded that drug was crystalline in nature due to the sharpness in peak height. Sharpness in peaks was decreased in microspheres that indicated drug in the both the formulation goes to the amorphous nature which can enhance bioavailability.SEM showed that microspheres of drug with ethyl cellulose and eudragit RS 100 were smooth and porous almost spherical microspheres. The rough surface which may be due to presence of drug crystals on the surface of microspheres. |
| Keywords: | XRD, Drug, floating drug delivery systems, gastric residence time, |
| Cite Article: | "FORMULATION AND EVALUATION OF GASTRORETENTIVE (FLOATING) DRUG DELIVERY SYSTEM OF ANTI- METABOLITE DRUG.", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 7, page no.160 - 166, July-2024, Available :http://www.ijrti.org/papers/IJRTI2407016.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2407016
Registration ID:190116
Published In: Volume 9 Issue 7, July-2024
DOI (Digital Object Identifier):
Page No: 160 - 166 Country: -, -, India Research Area: Other Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2407016 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2407016 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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