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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 105
Article Submitted : 11938
Article Published : 5968
Total Authors : 15688
Total Reviewer : 599
Total Countries : 108
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| Paper Title: | DESIGN AND DEVLOPMNT OF FLOATING DRUG DELIVERY SYSTEM OF FAMOTIDINE |
| Authors Name: | Monali T. Dhapate , Manoj Shirbhate |
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| Author Reg. ID: |
IJRTI_190115
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| Published Paper Id: | IJRTI2407015 |
| Published In: | Volume 9 Issue 7, July-2024 |
| DOI: | |
| Abstract: | The purpose of this investigation was to prepare a floating drug delivery system of famotidine. Famotidine having poor absorption in acidic environment (upper GIT). When given orally, it shows the bioavailability near to 50%. To overcome these drawbacks, the present study was undertaken to investigate the floating dosage form of famotidine. The prepared tablets were evaluated for content uniformity, hardness, friability, buoyancy, swelling index and in-vitro dissolution studies. Further selected formulation was subjected for short term stability studies for one and two month at temperature of 25°c and 40°c respectively.XRD graph of pure 5-Fluorouracil drug. It is concluded that drug was crystalline in nature due to the sharpness in peak height. Sharpness in peaks was decreased in microspheres that indicated drug in the both the formulation goes to the amorphous nature which can enhance bioavailability.SEM showed that microspheres of drug with ethyl cellulose and eudragit RS 100 were smooth and porous almost spherical microspheres. The rough surface which may be due to presence of drug crystals on the surface of microspheres. |
| Keywords: | XRD, Drug, floating drug delivery systems, gastric residence time |
| Cite Article: | "DESIGN AND DEVLOPMNT OF FLOATING DRUG DELIVERY SYSTEM OF FAMOTIDINE", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 7, page no.149 - 159, July-2024, Available :http://www.ijrti.org/papers/IJRTI2407015.pdf |
| Downloads: | 000204757 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2407015
Registration ID:190115
Published In: Volume 9 Issue 7, July-2024
DOI (Digital Object Identifier):
Page No: 149 - 159 Country: -, -, India Research Area: Other Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2407015 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2407015 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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