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Glidants are the substances that enhance the flow characteristics pf powder mixture. To get desired effect, these are added as a dry powder before the compression process. Glidants can show their effect at certain optimum concentration only. Above certain concentration glidants itself inhibit or decreases the good flow or flow properties. Glidants act by decreasing the overall surface charge present on the blend decreasing friction between particles and filling the gaps on the surface, thus further enhancing the rate of movement and flow. Glidants are additive materials that are used to improve a powder's flowability by lowering surface charge, cohesion, and interparticle friction all of which lower the angle of repose. Angle of repose is the maximum angle between the free standing surface of powder and horizontal plane. Smaller angle indicates a good flow property compared to bigger angle. Glidants also show impact on the flow properties, product quality, granulation, particle size, uniform distribution, tablet die cavity. Glidants play vital role in pharmaceutical industry for better quality of products. Various glidants used in pharmaceutical industry are Talc, Magnesium oxide, Magnesium silicate, Silicon dioxide, etc.
Keywords:
Glidant, Granules, Flowability, Angle of Repose
Cite Article:
"Impact of Variety of Glidants on Granulation Properties", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 7, page no.14 - 30, July-2024, Available :http://www.ijrti.org/papers/IJRTI2407003.pdf
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000204761
ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator