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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Volume 10 | Issue 9
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 112
Article Submitted : 17346
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Total Authors : 20065
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| Paper Title: | Analytical Method Development and Validation for The Simultaneous Determination of Tadalafil and Tamsulosin Hydrochloride by UHPLC in Oral Solid Dosage Forms |
| Authors Name: | Karunagaran k , Nalini C N , Bharani Pandilla |
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IJRTI_189948
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| Published Paper Id: | IJRTI2406002 |
| Published In: | Volume 9 Issue 6, June-2024 |
| DOI: | |
| Abstract: | Tamsulosin hydrochloride and Tadalafil belongs to a class of Alpha blockers drug used to treat Erectile dysfunction during sexual stimulation. The Ultra High Performance Liquid Chromatography method was used to develop and validate a new combination method of Tamsulosin-hcl and Tadalafil in a simple, accurate, rapid and simultaneous assay. The separation was done on an X-Bridge C18 column (4.6 × 50 mm: 3 microns) with a mobile phase of Ethyl Acetate: Toluene: Methanol: Ammonia (3:2:5:0.6) in isocratic mode and pumped according to flow rate. 0.5 ml/min and the compound was detected at 210 nm. Run time was 5 minutes. The retention time was 2.5 minutes and 3.1 minutes for tamsulosin hydrochloride and tadalafil. The % determination was 99.83% for Tam HCI and 100.78% for Tad. The retention time and run time were simple, fast and economical, which can be applied in regular quality control tests in the pharmaceutical industry. |
| Keywords: | Tamsulosin hydrochloride, Tadalafil, UHPLC, Method Development, Oral Solid Dosage Forms. |
| Cite Article: | "Analytical Method Development and Validation for The Simultaneous Determination of Tadalafil and Tamsulosin Hydrochloride by UHPLC in Oral Solid Dosage Forms", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 6, page no.6 - 13, June-2024, Available :http://www.ijrti.org/papers/IJRTI2406002.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2406002
Registration ID:189948
Published In: Volume 9 Issue 6, June-2024
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Page No: 6 - 13 Country: Chennai, Tamilnadu, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2406002 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2406002 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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