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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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| Paper Title: | DEVELOPMENT AND VALIDATION OF RP-HPLC METHODS FOR SIMULTANEOUS ESTIMATION OF SILDENAFIL CITRATE AND TRAMADOL HYDROCHLORIDE IN SYNTHETIC MIXTURE |
| Authors Name: | Yuvrajsinh Solanki , Prof. Priyanka Malani , Dr. Umesh Upadhyay |
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IJRTI_186870
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| Published Paper Id: | IJRTI2305183 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | |
| Abstract: | It is simple, sensitive and accurate RP-HPLC method was developed for simultaneous estimation for Sildenafil citrate and Tramadol hydrochloride. A reversed–phase high-performance liquid chromatography method is developed and validated for the determination of both drugs with the help of RP-HPLC it gives us to good resolution and better separation for the both drugs. The separation was conducted by using Shim pack C18 column (250 mm×4.6 mm×5 µm) with mobile phase consisting Acetonitrile: Methanol: Water (5:75:20 v/v/v) Ph 4.5 Orthophosphoric acid. The mobile phase was delivered at the flow rate of 1.0 ml/min. The eluent was monitored at wavelength 274 nm and found shorter retention time of Drug and peak shape was proper, resolution good of Sildenafil citrate and Tramadol hydrochloride were found to be 6.17 min and 9.05 min respectively. The method was validated for linearity, accuracy, precision, system suitability, and stability. The method was found to be linear over the concentration range for SIL was 5-25 µg/ml and for TRA was 10-50 µg/ml with coefficient R2 for SIL 0.9991 and TRA 0.9996. Therefore, proposed method can be successfully used for routine analysis of Sildenafil citrate and Tramadol hydrochloride in bulk as well as synthetic mixture. |
| Keywords: | Sildenafil citrate (SIL), Tramadol hydrochloride (TRA), Reversed-Phase-High performance Liquid Chromatography (RP-HPLC). |
| Cite Article: | "DEVELOPMENT AND VALIDATION OF RP-HPLC METHODS FOR SIMULTANEOUS ESTIMATION OF SILDENAFIL CITRATE AND TRAMADOL HYDROCHLORIDE IN SYNTHETIC MIXTURE", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 5, page no.2008 - 2015, May-2023, Available :http://www.ijrti.org/papers/IJRTI2305183.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2305183
Registration ID:186870
Published In: Volume 8 Issue 5, May-2023
DOI (Digital Object Identifier):
Page No: 2008 - 2015 Country: -, -, - Research Area: Engineering Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2305183 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2305183 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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