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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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| Paper Title: | DEVELOPMENT AND VALIDATION OF RP-HPLC METHODS FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND LINAGLIPTIN IN SYNTHETIC MIXTURE |
| Authors Name: | Shubham Pandya , Dr. Priyanka Patil , Mrs. Krishna Kalsara , Dr. Umesh Upadhyay |
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IJRTI_186866
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| Published Paper Id: | IJRTI2305182 |
| Published In: | Volume 8 Issue 5, May-2023 |
| DOI: | |
| Abstract: | It is simple, sensitive and accurate RP-HPLC method was developed for simultaneous estimation for Dapagliflozin and Linagliptin A reversed–phase high-performance liquid chromatography method is developed and validated for the determination of both drugs. With the help of RP-HPLC it gives us to good resolution and better separation for the both drugs. The separation was conducted by using Shim Pack C18 column (250 mm×4.6 mm×5 µm) with mobile phase consisting Phosphate buffer, Methanol Sodium and ACN (40:30:30 )% v/v/v. The mobile phase was delivered at the flow rate of 1.0 ml/min. The eluent was monitored at wavelength 223 nm and found a sharp and symmetrical peak of Dapagliflozin and Linagliptin were found to be 9.205 min and 2.908 min respectively. The method was validated for linearity, accuracy, precision, system suitability. The method was found to be linear over the concentration range for both drugs 5-30µg/ml with coefficient R2 for DAP 0.9991 and LIN 0.9992. Therefore, proposed method can be successfully used for routine analysis of Dapagliflozin and Linagliptin in bulk as well as synthetic mixture. |
| Keywords: | Dapagliflozin (DAP), Linagliptin (LIN), Reversed-Phase-High performance Liquid Chromatography (RP-HPLC) |
| Cite Article: | "DEVELOPMENT AND VALIDATION OF RP-HPLC METHODS FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND LINAGLIPTIN IN SYNTHETIC MIXTURE", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 5, page no.2001 - 2007, May-2023, Available :http://www.ijrti.org/papers/IJRTI2305182.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2305182
Registration ID:186866
Published In: Volume 8 Issue 5, May-2023
DOI (Digital Object Identifier):
Page No: 2001 - 2007 Country: Vadodara, Gujrat, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2305182 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2305182 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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