UGC CARE norms ugc approved journal norms IJRTI Research Journal

WhatsApp
Click Here

International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.14 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

Call For Paper

For Authors

Forms / Download

Published Issue Details

Editorial Board

Other IMP Links

Facts & Figure

Impact Factor : 8.14

Issue per Year : 12

Volume Published : 8

Issue Published : 82

Article Submitted : 6414

Article Published : 3411

Total Authors : 8699

Total Reviewer : 545

Total Countries : 75

Indexing Partner

Licence

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Published Paper Details
Paper Title: Biodegradable Microspheres for Captopril Drug Delivery
Authors Name: Rima Farag Elmzughi , Mokhtar M. El-Baseir
Download E-Certificate: Download
Author Reg. ID:
IJRTI_185333
Published Paper Id: IJRTI2303029
Published In: Volume 8 Issue 3, March-2023
DOI:
Abstract: Abstract This paper presents formulation and evaluation of Poly (L-Lactide) microspheres for captopril delivery. Microspheres were prepared using water in oil in water (W/O/W) solvent evaporation method. The microspheres were evaluated for the yield, particle size and surface morphology using scanning electron microscopy (SEM). Entrapment efficiency and drug loading were assayed using UV-visible spectrophotometric system. In-vitro drug release was conducted in phosphate buffer (pH 7.4) and in 0.1 N HCl (pH 1.2) as dissolution medium. FTIR spectroscopy was used to study any interaction between the drug and components of the microparticles. Results showed that the method was suitable for formulating microspheres with an average particle size of 3.62 ± 0.35 µm having entrapment efficiency of captopril up to 98.74 %. SEM characterization results showed that the microspheres have spherical shape and smooth surface. Drug-polymer ratio was found to alter the microspheres yield and entrapment efficiency. FTIR study revealed the absence of any interaction between the components of the microspheres. The drug release study showed that microspheres were able to sustain the release of captopril up to 6 hrs in acidic media (pH 1.2) and up to 30 min in phosphate buffer (pH 7.4). The mechanism of drug release of captopril in phosphate buffer is suggested to be via diffusion process and to follow Korsmeyer-Peppas model. It is possible to sustain the release of captopril using poly (L-Lactide)microspheres.
Keywords: Key words: Biodegredable-Polymeric microspheres, Poly (L-Lactide), Captopril, Mechanism of drug release.
Cite Article: "Biodegradable Microspheres for Captopril Drug Delivery", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 3, page no.180 - 186, March-2023, Available :http://www.ijrti.org/papers/IJRTI2303029.pdf
Downloads: 00041
ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2303029
Registration ID:185333
Published In: Volume 8 Issue 3, March-2023
DOI (Digital Object Identifier):
Page No: 180 - 186
Country: Tripoli, Tripoli, Libyan Arab Jamahiriya
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2303029
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2303029
Share Article:

Share Facebook Twitter Google+ Pinterest LinkedIn Email Tumblr WhatsApp Google Gmail

Click Here to Download This Article

Article Preview
Click Here to Download This Article
Major Indexing from www.ijrti.org
Google Scholar ResearcherID Thomson Reuters Mendeley : reference manager Academia.edu
arXiv.org : cornell university library Research Gate CiteSeerX DOAJ : Directory of Open Access Journals
DRJI Index Copernicus International Scribd DocStoc

ISSN Details

ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

DOI (A digital object identifier)


Providing A digital object identifier by DOI.ONE
How to Get DOI?

Conference

Open Access License Policy

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Creative Commons License This material is Open Knowledge This material is Open Data This material is Open Content

Important Details

Social Media

Join RMS/Earn 300
IJRTI

Indexing Partner
Copyright © 2023 - All Rights Reserved - IJRTI