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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
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| Paper Title: | Formulation Development of Fast Disintegrating Tablet of Metformin Hcl and Optimization of Disintegration Time and Friability by QbD Method |
| Authors Name: | Anita H. Pagar , Shital M. Bagul , Dipika H. Patil , Bharati D.Aher |
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IJRTI_185167
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| Published Paper Id: | IJRTI2302009 |
| Published In: | Volume 8 Issue 2, February-2023 |
| DOI: | |
| Abstract: | Abstract: Objective: to formulate and characterized fast disintegrating tablet of Metformin Hcl to produce intended benefits. Methods: Tablets were prepared using a direct compression method employing superdisintegrants such as Sodium starch glycolate, Crosscarmellose Na, Microcrystalline cellulose. Tablets of Metformin Hcl prepared using sodium starch glycolate least disintegration time compare to Crosscarmellose Na, Microcrystalline cellulose Results: An optimized formulation was found to have good hardness, wetting time, disintegrating time.F6 formulation is showing less friability and less disintegration time and drug release at constant rate as well as fast rate. Stability studies indicated that there are no significant changes in hardness, Percentage friability, drug content and in-vitro disintegration time and cumulative percentage drug release. Conclusions: Thus it was concluded that by adopting a systematic formulation approach, Metformin Hcl fast disintegrating tablet could be formulated using superdisintegrants shows improved therapeutic efficacy. By direct compression method were found to be good and were free from capping and chipping. Based on the in –vitro disintegration time, Formulation F6 were found to be promising and showed a dispersion time of 22 sec., wetting time of 48 and 64 sec respectively, which facilitate the faster dispersion in the mouth. |
| Keywords: | Keywords: Fast disintegrating tablet, Metformin Hcl, Sodium starch glycolate, Crosscarmellose Na, Microcrystalline cellulose. |
| Cite Article: | "Formulation Development of Fast Disintegrating Tablet of Metformin Hcl and Optimization of Disintegration Time and Friability by QbD Method", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 2, page no.48 - 65, February-2023, Available :http://www.ijrti.org/papers/IJRTI2302009.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2302009
Registration ID:185167
Published In: Volume 8 Issue 2, February-2023
DOI (Digital Object Identifier):
Page No: 48 - 65 Country: Dist- Nashik , maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2302009 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2302009 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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