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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | A COMPREHENSIVE REVIEW ON THERAPEUTIC APPROACHES OF NANO PARTICLES IN CANCER THERAPY |
| Authors Name: | Krishna Prasad Davarasingi , Yatam Sri Ram Tarun Kumar , Palivela Durga Chandra Vamshi , Abbas Ali , Nori Lakshmi Prasanthi |
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IJRTI_185054
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| Published Paper Id: | IJRTI2301016 |
| Published In: | Volume 8 Issue 1, January-2023 |
| DOI: | |
| Abstract: | Nanotechnology has been extensively studied and exploited for cancer treatment as nanoparticles can play a significant role as a drug delivery system. Compared to conventional drugs, nanoparticle-based drug delivery has specific advantages, such as improved stability and biocompatibility, enhanced permeability and retention effect, and precise targeting. The application and development of hybrid nanoparticles, which incorporates the combined properties of different nanoparticles, has led this type of drug-carrier system to the next level. In addition, nanoparticle-based drug delivery systems have been shown to play a role in overcoming cancer-related drug resistance. The mechanisms of cancer drug resistance include overexpression of drug efflux transporters, defective apoptotic pathways, and hypoxic environment. Nanoparticles targeting these mechanisms can lead to an improvement in the reversal of multidrug resistance. Furthermore, as more tumor drug resistance mechanisms are revealed, nanoparticles are increasingly being developed to target these mechanisms. Moreover, scientists have recently started to investigate the role of nanoparticles in immunotherapy, which plays a more important role in cancer treatment. In this review, we discuss the roles of nanoparticles and hybrid nanoparticles for drug delivery in chemotherapy, targeted therapy, and immunotherapy and describe the targeting mechanism of nanoparticle-based drug delivery as well as its function on reversing drug resistance. Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem like cells growth. Nanomaterials are materials in the nonorange 1–100 nm which possess unique optical, magnetic, and electrical properties. Nanomaterials used in cancer therapy can be classified into several main categories. Targeting cancer cells, tumor microenvironment, and immune system, these nanomaterials have been modified for a wide range of cancer therapies to overcome toxicity and lack of specificity, enhance drug capacity as well as bioavailability. |
| Keywords: | Nanoparticle, drug delivery, hybrid nanoparticles, targeted cancer therapy, drug resistance. |
| Cite Article: | "A COMPREHENSIVE REVIEW ON THERAPEUTIC APPROACHES OF NANO PARTICLES IN CANCER THERAPY", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 1, page no.88 - 94, January-2023, Available :http://www.ijrti.org/papers/IJRTI2301016.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2301016
Registration ID:185054
Published In: Volume 8 Issue 1, January-2023
DOI (Digital Object Identifier):
Page No: 88 - 94 Country: Bhimavaram, Andhra Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2301016 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2301016 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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