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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

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Paper Title: Ocular In Situ Gel - A Review
Authors Name: Vishal Sanjay Shinde , S.B.Shinde
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IJRTI_184312
Published Paper Id: IJRTI2210045
Published In: Volume 7 Issue 10, October-2022
DOI:
Abstract: The eye is the body's most delicate organ. Because of the complicated anatomical structure of the eye, designing an ocular drug delivery system is the most difficult task for pharmaceutical scientists. Less than 5% of administered drugs enter the eye.poor corneal transparency, a tiny absorptive surface, and corneal lipophilicity drug's bonding with the epithelium, pre-corneal loss (due to nasolacrimal drainage), and proteins in tear fluid, blinking, and a small conjunctival sac, which limit the drug's molecule entering the place of action, which ultimately results in poor ocular health therapy. Numerous studies in this field support the idea that in situ gelling systems are advantageous for delivering drugs to the eyes. In situ gel forming systems are drug delivery systems that are in solution form before administration in the body but once administered, undergo in situ gelation, to a gel triggered by external stimulus such as temperature, pH etc.Ocular In-situ gelling systems are a new class of eye drug delivery systems that are initially in solution but are quickly transformed into a viscous gel when introduced or inserted into an ocular cavity where active drugs are released continuously. This sol-to-gel phase conversion depends on a variety of factors such as changes in pH, ion presence, and temperature changes. In contrast to typical eye drops, post-transplanting gel chooses viscosity and bio-adhesive qualities that lengthen the gel's stay in the ocular area and also release the medicine in a long, continuous manner and lotions. In these articles, ophthalmic medication delivery systems are classified.Review of situ gel system, gel system mechanism, polymers employed, and evaluations.
Keywords: Ocular ,Gel ,Anatomy , Barrier, Drug delivery.
Cite Article: "Ocular In Situ Gel - A Review", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 10, page no.337 - 347, October-2022, Available :http://www.ijrti.org/papers/IJRTI2210045.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2210045
Registration ID:184312
Published In: Volume 7 Issue 10, October-2022
DOI (Digital Object Identifier):
Page No: 337 - 347
Country: Ahmednagar, Maharashtra, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2210045
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2210045
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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