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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Toxicological Evaluation of Soil Polychlorinated Biphenyls (PCBs) extracted from Dumpsites on Liver of Albino Rats (Rattus novergicus) |
| Authors Name: | Fajinmi Victor oluwafemi , Fajinmi Beatrice , Onojeghuo Erere , Akpobaro Austin , Akpomedaye Cletus |
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IJRTI_184023
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| Published Paper Id: | IJRTI2209073 |
| Published In: | Volume 7 Issue 9, September-2022 |
| DOI: | |
| Abstract: | Environmental contamination of PCBs may occur from the disposal of old electrical equipment containing PCBs. Their characteristic low solubility contributes to their ability to bioconcentrate which leads to bioaccumulation. This study evaluates mechanism underlying toxic damage to the liver induced by PCBs extracted from soil of three dumpsites. Oral administration of extracted PCBs and co-administration with vitamin C after two weeks the liver of each rat was isolated and homogenized for toxicological studies. It was found that administration of PCBs significantly (p<0.05) reduced activity of AST relative to Control, co-administration of vitamin C with PCBs significantly increased (p<0.05) liver AST compared with PCBs only but was still significantly lower (p<0.05) relative to Control. Groups 3 and 5 MDA is about 2 ½ and 2 folds respectively that of Control. GSH concentration of liver of rats in Groups 3-8 was significantly lower (p<0.05) relative to the Control. The present study has shown that PCBs induce toxic stress on the liver as evidenced by enzymes activities. Although the mechanism whereby PCBs induce toxic stress on the liver is not fully elucidated in this study, we have however shown that PCBs interferes with protein and carbohydrate metabolisms in the liver by loss of ALT and AST activity. |
| Keywords: | Polychlorinated biphenyls (PCBs) soil, rats, SOD, CAT, MDA, ALT, ACP, ALP, GGT, LDH, Toxicity. |
| Cite Article: | "Toxicological Evaluation of Soil Polychlorinated Biphenyls (PCBs) extracted from Dumpsites on Liver of Albino Rats (Rattus novergicus)", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 9, page no.565 - 571, September-2022, Available :http://www.ijrti.org/papers/IJRTI2209073.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2209073
Registration ID:184023
Published In: Volume 7 Issue 9, September-2022
DOI (Digital Object Identifier):
Page No: 565 - 571 Country: Warri, Delta , Nigeria Research Area: Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2209073 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2209073 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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