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Breast cancer is a major public health problem for women throughout the world, being the leading cause of cancer death amongst females after carcinoma lung. Treatment of carcinoma breast is multimodal including surgery, radiotherapy, chemotherapy, and the hormonal therapy depending upon the HPE and IHC reports((ER, PR, HER-2-NEU and Ki 67). We conducted an observational study in which the HPE and IHC reports before and after the administration of systemic therapy in the patients with locally advanced breast cancer (LABC) was compared. The preoperative HPE and IHC reports were obtained by the core needle biopsy. Response of the disease so obtained after the NACT was evaluated with RECIST criteria and depending on the type of response (complete and partial) , patients were subjected to surgical treatment (Modified radical mastectomy ) The final reports of HPE and IHC of MRM specimen thus obtained was compared with preNACT HPE and IHC eeport.. From our study we concluded that NACT brings about a change in the ER, PR, HER-2-NEU and Ki-67 receptor status in carcinoma breast which can change the management of the patient in view of target based therapy and hormonal therapy in the post operative period.
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Cite Article:
"TO STUDY THE RECEPTOR STATUS BEFORE AND AFTER NEOADJUVANT CHEMOTHERAPY IN BREAST CARCINOMA", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 9, page no.132 - 134, September-2022, Available :http://www.ijrti.org/papers/IJRTI2209016.pdf
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ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator