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Microsponges are at the leading edge of the rapidly developing novel drug delivery technology field. The microsponge-based drug delivery system is a unique technology for a controlled release system and enhanced drug deposition within the skin while minimizing transdermal penetration of topically active agents. Drug-loaded microsponge consists of microporous beads, typically 10-25 μm in diameter. When applied to the skin, the microsponge releases its active ingredient on a time mode and also in response to other stimuli like rubbing, pressure, temperature, pH, etc. Microsponge technology offers entrapment of active ingredients and is believed to contribute to reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. additionally, it's non-irritating, non-allergenic, non-mutagenic, and non-toxic. This technology is being employed currently in cosmetics, over-the-counter skincare, sunscreen, and prescription products [12].
Vitamin A is the most multifunctional vitamin within the anatomy and constitutes a gaggle of organic lipid-soluble compounds comprising retinol and its derivatives, mainly the retinol esters, retinyl palmitate, and retinyl acetate. Retinol is deeply involved in growth and maintenance thanks to its cellular contribution to cell proliferation and differentiation from early embryogenesis to adulthood. Topical retinoids are used for the clinical treatment of psoriasis, hyperkeratosis, acne, early aging, and photodamage. However, its high instability hence oil and water-soluble microsponge delivery of the retinol has been developed [16].
Keywords:
Microsponge drug delivery system, retinol,Controlled release, Porous microspheres
Cite Article:
"A REVIEW: RETINOL- INFUSED PRODUCTS BY MICROSPONGE TECHNOLOGY", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 9, page no.24 - 36, September-2022, Available :http://www.ijrti.org/papers/IJRTI2209004.pdf
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ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator