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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 11
Issue Published : 118
Article Submitted : 21544
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Total Authors : 22414
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| Paper Title: | Synoptic Review On Ophthalmic In-SITU Gel System |
| Authors Name: | Prerana S Husukale , Dr. I.D.Gonjari |
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| Author Reg. ID: |
IJRTI_183803
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| Published Paper Id: | IJRTI2208221 |
| Published In: | Volume 7 Issue 8, August-2022 |
| DOI: | |
| Abstract: | Ophthalmic drug delivery is one of the most fascinating and difficult endeavours facing pharmaceutical scientists. The main issue encountered by pharmaceutical scientists is rapid precorneal elimination of the drug, resulting in poor bioavailability and therapeutic response due to high tear fluid turnover and dynamics. These benefits, including ease of administration, decreased frequency of administration, improved patient compliance, and comfort, have sparked interest in in situ forming polymeric delivery systems. The development of gels, which allow for the sustained and controlled release of drugs, is dependent on variables including temperature variation, pH changes, the presence of ions, and ultraviolet radiation. In situ-forming gels are liquid when applied, go through a phase change in the ocular cul de sac to become visco-elastic gel, and respond to environmental changes as a result. A significant number of novel temperature, pH, and ion induced in situ-forming systems have been reported in the recent years for sustained ophthalmic drug delivery. Each system has unique benefits and drawbacks. The selection of a specific gel is based on its inherent qualities and intended therapeutic use. In situ gels are now employed as delivery systems for drugs that have both local and systemic effects. The fundamentals of the in situ gel system are discussed in this review. Such devices are easier to produce from a manufacturing standpoint, which reduces investment and manufacturing costs. |
| Keywords: | In-Situ Gel, Poor bioavailability, Controlled release, Sustained release, Ophthalmic |
| Cite Article: | "Synoptic Review On Ophthalmic In-SITU Gel System", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 8, page no.1361 - 1365, August-2022, Available :http://www.ijrti.org/papers/IJRTI2208221.pdf |
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| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2208221
Registration ID:183803
Published In: Volume 7 Issue 8, August-2022
DOI (Digital Object Identifier):
Page No: 1361 - 1365 Country: Satara, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2208221 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2208221 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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