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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 109
Article Submitted : 16095
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| Paper Title: | Phytochemical Screening and Comparative Study of the Effects of Serial Extracts of Solanum Aculeastrum Seeds on Serum Lipid Profile of Testosterone Propionate Induced Benign Prostatic Hyperplasia in Male Wistar Rats |
| Authors Name: | Joseph Anna Ubon , Monday Isaiah Akpanabiatu , Justina Ime Rufus Udotong , Udeme Ededem Okon |
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IJRTI_183214
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| Published Paper Id: | IJRTI2207246 |
| Published In: | Volume 7 Issue 7, July-2022 |
| DOI: | |
| Abstract: | The phytochemical analysis and serum lipid profile of male Wistar rats following oral administration of serial extracts of solanum acculeastrum seeds were evaluated and compared. Finely ground Solanum aculeastrum seeds (1000 g) were extracted with hexane, chloroform, benzene, ethylacetate and ethanol respectively using serial exhaustive extraction technique. Male Wistar rats weighing 280 ± 20g were injected with 10 mg/kg body weight of Testosterone Propionate through intraperitoneal route for twenty eight days to induce BPH. The animals were divided into eight (8) groups of six (6) rats each. Group 1 (Normal control) was not induced with BPH and served as normal control, group 2 was induced and not treated and served as BPH control, group 3 (Finasteride control) was induced and received standard drug, finasteride while groups 4 (Hexane extract treated group), 5 (Chloroform extract treated group), 6 (Benzene extract treated group), 7 (Ethylacetate extract treated group) and 8 (Ethanol extract treated group) were induced and treated orally with 300 mg/kg body weight of hexane, chloroform, benzene, ethylacetate and ethanol extracts respectively for twenty eight days. The animals were sacrificed and blood collected through cardiac puncture. Biochemical studies were conducted using standard procedures. Steroids, alkaloids, flavonoids, phenols, tannins, cardiac glycosides, coumarins, terpenoids, proteins and reducing sugars were detected. The yield (g/ 100 g) of flavonoids was maximum (11.07), followed by phenols (0.327). TC, TG and VLDL-C levels were not significantly altered except in chloroform extract where significant increase in LDL-C levels was observed. Hexane extract exhibited the best effect compared to the standard drug. These results suggest that all the serial extracts may be safe for use in the management of BPH and support its therapeutic use by the herbalists in treating inflammatory diseases. |
| Keywords: | Solanum acculeastrum, BPH, Lipid profile, Phytochemicals, Wistar rats. |
| Cite Article: | "Phytochemical Screening and Comparative Study of the Effects of Serial Extracts of Solanum Aculeastrum Seeds on Serum Lipid Profile of Testosterone Propionate Induced Benign Prostatic Hyperplasia in Male Wistar Rats", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 7, page no.1575 - 1584, July-2022, Available :http://www.ijrti.org/papers/IJRTI2207246.pdf |
| Downloads: | 000204911 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2207246
Registration ID:183214
Published In: Volume 7 Issue 7, July-2022
DOI (Digital Object Identifier):
Page No: 1575 - 1584 Country: Uyo, Akwa Ibom, Nigeria Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2207246 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2207246 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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