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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | Formulation and evaluation of Herbal Anti-Fungal Nail Lacquer |
| Authors Name: | Srushti Mahesh Bendale , Minal R. Narkhade , Yash S. Agrawal |
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| Author Reg. ID: |
IJRTI_183203
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| Published Paper Id: | IJRTI2207172 |
| Published In: | Volume 7 Issue 7, July-2022 |
| DOI: | |
| Abstract: | Introduction:-Around 19% of the world population is suffering from onychomycosis among which 80% cases of Onychomycosis have affected toenails. The infection is associated with proximal subungalonychomycosis distal and primary total dystrophic onychomycosis. There are varieties of formulation for treatment of nails infection like creams, solution, gel, nail patches. Nail is the less vascular area. Therefore, nail lacquer will be more effective formulation than other formulation mainly oral administration. The objective of the present study is to formulate and evaluate the Anti-Fungal nail lacquer using various herbs. To screen Anti-Fungal activity of formulated nail lacquer. To find out effective concentration of penetration enhancer. Method: - Nail lacquer was prepared by using nitrocellulose, ethyl cellulose, ethyl acetate, salicylic acid (act as penetration enhancer), dibutylphthalate and various mixture of extract of Calendula officinalis, Origanum vulgare, Allium sativum, and oils of Syzygium aromaticum, Melaleuca alternifolia, cymbopogon, Ocimumtenuflorum and Menthapiperita.The mixture of extract and oils mixed with the continuous stirring. The nail lacquer of Fluconazole was prepared by same method and compare for Anti-Fungal activity with formulated herbal nail lacquer. Herbal nail lacquer were evaluated for appearance, non-volatile content, lacquer film thickness, drying time, gloss, smoothness, flow, water resistance test, peel adhesion test, Anti-fungal study. Result:-The evaluation results revealed the nonvolatile content helped for film making by evaporation of volatile content, the glossiness was visually seen required to accept medicated nail lacquer, it show good antifungal activity, the drying time increase as concentration of penetration enhancer increase, the flow was found to be smooth and the appearance was observed . Herbal nail lacquer showed improved antifungal activity as compare to Fluconazole. Conclusion- The extract loaded nail lacquer was successfully delivered through nail plate. The penetration enhancer proved to enhance transungual delivery. Herbal nail lacquer shows good antifungal activity. It could be a good choice of antifungal agent and accepted by patient due to natural appeal. |
| Keywords: | Polyherbal Nail Lacquer, Antifungal, Onychomycosis |
| Cite Article: | "Formulation and evaluation of Herbal Anti-Fungal Nail Lacquer ", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 7, page no.1094 - 1100, July-2022, Available :http://www.ijrti.org/papers/IJRTI2207172.pdf |
| Downloads: | 000204904 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2207172
Registration ID:183203
Published In: Volume 7 Issue 7, July-2022
DOI (Digital Object Identifier):
Page No: 1094 - 1100 Country: Nashik, Maharashtra , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2207172 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2207172 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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