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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | In-sillo study of Indian plants as the potential inhibitor's against SARS-COV-2 main protease (MPRO)and spike (s) receptor. |
| Authors Name: | Shital Narayan Chavan |
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| Author Reg. ID: |
IJRTI_182851
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| Published Paper Id: | IJRTI2206306 |
| Published In: | Volume 7 Issue 6, July-2022 |
| DOI: | |
| Abstract: | Coronavirus disease 2019 (COVID-19) is an infectious disease caused by Severe acute Respiratory syndrome virus-2 (SARS CoV-2) temporarily named this pathogen as 2019 novel coronavirus (2019-nCoV) is a single positive strand RNA betacoronavirus (CoV).The coronavirus polyprotein encodes two proteases, which share in its processing and release of the translated nonstructural proteins (NSPs), the main protease is called 3-chymotrypsin-like protease (3CL pro) and a papainlike protease (PL pro).12 Both main protease (3CLpro and PLpro) an attractive drug target for drug discovery studies due to its essential role in processing the polyprotein that are translated from the viral RNA. Lack of an effective vaccine and/or antiviral drugs against SARSCoV-2, the causative agent, has severely hampered the response to this novel coronavirus. Natural products have long been used in traditional medicines to treat various diseases, and purified phytochemicals from Indian medicinal plants provide a valuable scaffold for the discovery of new drug leads. In the present study, we performed a computational screening of a database composed of 50 potent phytochemicals derived from Indian medicinal plants with bronchodilator activity. Structure-based virtual screening was carried out against SARS COV-2 main protease. to identify reputed inhibitors that could facilitate the development of potential anti- COVID-19 drug candidates. Considering the ebselen as a reference, we observed that the inhibition potentials of carotene, glychrhizinic acid are very effective. The inhibitory efficiency of other phytochemical constituents also possesses specific inhibition properties against Covid-19 main protease. These potential phytochemical will be subjected to further in vitro and in vivo studies and may assist the development of effective anti-COVID-19 drugs. |
| Keywords: | Keywords: Coronavirus 19, Spike protein, Natural products, auto-dock vina, carotene |
| Cite Article: | "In-sillo study of Indian plants as the potential inhibitor's against SARS-COV-2 main protease (MPRO)and spike (s) receptor.", International Journal for Research Trends and Innovation (www.ijrti.org), ISSN:2456-3315, Vol.7, Issue 6, page no.2033 - 2048, July-2022, Available :http://www.ijrti.org/papers/IJRTI2206306.pdf |
| Downloads: | 000205489 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2206306
Registration ID:182851
Published In: Volume 7 Issue 6, July-2022
DOI (Digital Object Identifier):
Page No: 2033 - 2048 Country: Beed , Maharashtra , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2206306 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2206306 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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