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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 115
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Total Authors : 21252
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| Paper Title: | Investigation of anti-inflammatory and anti-cancer activity of leaf extracts and fractions of Lantana camara linn |
| Authors Name: | Sachin Rathod , Shridharkumar S.B , B. Naipunya , Ruksana N. |
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| Author Reg. ID: |
IJRTI_188775
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| Published Paper Id: | IJRTI2312100 |
| Published In: | Volume 8 Issue 12, December-2023 |
| DOI: | |
| Abstract: | Inflammation is when a wound swells up, turns red and hurts, it may be a sign of inflammation. Inflammation is the body’s immune system’s response to an irritant. the irritant might be a germ, but it could also be a foreign object. Pathogens, toxic mechanical and chemical agents, autoimmune reactions, and other stimuli can all cause inflammation. Hear the study was undertaken to investigate the possible anti-inflammation and anti-cancer activity of extract of leaf of Lantana camara linn in carrageenan induced rat paw oedema and MTT assay. For this current research leaf of Lantana camara linn was taken as a test drug. Carrageenan induced model, the oedema (inflammation) was developed in rats by intraperitoneal injection (IP) of carrageenan in normal saline i.e., 0.1ml of 1% Carrageenan sol followed by administration of test drug low dose 250mg/kg and higher dose 500mg/kg of body weight. After 1 to 5 Hrs the paw volume samples were collected to measure oedema (inflammation) levels as well as after 24hrs and then biological parameters paw volume were measured by using digital plethysmometer. Diclofenac sodium (10mg/kg) was used as standard drug for this study. So, the test drug shown significant decline in carrageenan induced paw volume whereas significant elevation of paw volume at 500mg/kg dose and the results were comparable with that of standard. MTT assay was conducted to assess the anticancer effects of the Methanolic extract of Lantana camara linn at different concentrations on HCT 29 cell lines. As observed by MTT assay, The extract decreased the HCT 29, cell viability in a concentration-dependent way. The result have-been shown that leaf of lantana camara linn have anti-cancer and anti-inflammation action. To isolate and identify that exact active constituents, additional research must be conducted. |
| Keywords: | Anti-Inflammation, Anti-Cancer, Lantana Camara Linn, 0.1ml Of 1% Carrageenan, HCT 29, Digital Plethysmometer |
| Cite Article: | "Investigation of anti-inflammatory and anti-cancer activity of leaf extracts and fractions of Lantana camara linn", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.8, Issue 12, page no.715 - 753, December-2023, Available :http://www.ijrti.org/papers/IJRTI2312100.pdf |
| Downloads: | 000205173 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID: IJRTI2312100
Registration ID:188775
Published In: Volume 8 Issue 12, December-2023
DOI (Digital Object Identifier):
Page No: 715 - 753 Country: Vijayapur, karnataka, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2312100 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2312100 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
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