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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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| Paper Title: | UPLC Method Development and Validation for Simultaneous Estimation of Terbutaline, Etofylline and Bromhexine HCL in Bulk and Solid Dosage Form |
| Authors Name: | Kaushik V S , Nalini C N , Vijayakumar R |
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IJRTI_189888
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| Published Paper Id: | IJRTI2405057 |
| Published In: | Volume 9 Issue 5, May-2024 |
| DOI: | |
| Abstract: | Terbutaline Sulphate, Etofylline & Bromhexine HCL belongs to a class of Bronchodilator drug used to treat Asthma and Emphysema. A simple, accurate, precise method was developed for the simultaneous estimation of the Terbutaline Sulphate, Etofylline & Bromhexine HCL in solid dosage form by using Ultra performance liquid chromatography (UPLC). Retention time of Terbutaline Sulphate was found 2.054 min, Etofylline was found 2.865 min & Bromhexine HCL was found 4.261min. % RSD of the Terbutaline Sulphate was found 1.08%, Etofylline was found 0.40% & Bromhexine HCL was found 0.30%. % Assay was obtained as 101.02% for Terbutaline Sulphate, 99.20% for Etofylline & 100.23% Bromhexine HCL. Regression equation of Terbutaline Sulphate y = 0.1967x - 0.0516 R² = 0.9999, Etofylline y = 1.7464x +0.1858 R² = 1.0000 & Bromhexine HCL is y = 13.3019x + 1.8664 R² = 0.9998. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries. |
| Keywords: | Terbutaline Sulphate, Etofylline, Bromhexine HCL, UPLC. |
| Cite Article: | "UPLC Method Development and Validation for Simultaneous Estimation of Terbutaline, Etofylline and Bromhexine HCL in Bulk and Solid Dosage Form", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.9, Issue 5, page no.389 - 397, May-2024, Available :http://www.ijrti.org/papers/IJRTI2405057.pdf |
| Downloads: | 000205186 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2405057
Registration ID:189888
Published In: Volume 9 Issue 5, May-2024
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Page No: 389 - 397 Country: Chennai, Tamilnadu, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2405057 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2405057 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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