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Impact Factor : 8.14

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Paper Title: RP-HPLC method to Determination and Validation of Paroxetine Hydrochloride in Bulk and Pharmaceutical Dosage Form
Authors Name: Kumaran S , C Sreedhar , Deepthi D Kini , T Sreenivasa Rao , Harsha K Tripathy
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Published Paper Id: IJRTI2210018
Published In: Volume 7 Issue 10, October-2022
Abstract: Purpose: This work makes an attempt to establish a sensitive and accurate method for the development and validation of an analytical method for estimation of Paroxetine hydrochloride in bulk and pharmaceutical dosage form. Methods: A mixture of 10 mM Ammonium acetate buffer pH 4.5 and methanol in the ratio of 65:35 (v/v %) was used as the mobile phase. An xBridge™ C18 column (250 mm x 4.6 mm, 5µ) was used for the analysis at a flow rate of 1 ml/min, injection volume of 20 µl, run time of 10 mins, and detection wavelength of 291 nm. The repeatability (within-day in triplicates) and intermediate precision (for two days) were carried out by six injections and the obtained results within and between the days of trials were expressed as % RSD. The linearity of the method was determined by the analysis of analyte concentration across a range of 10μg/ml to 60μg/ml. Results: The %RSD values of precision studies were found to be below the accepted limit of 2%. The method was found to be linear with a correlation coefficient (R2) of 0.999. The method was also found to be accurate and robust with suitable values. The LOD and LOQ of the method were found to be 0.44 µg/ml and 1.48 µg/ml respectively. Conclusion: The results of the analysis prove that this method can be used for the routine determination of Paroxetine Hydrochloride in bulk drug and in pharmaceutical dosage forms.
Keywords: Paroxetine Hydrochloride, RP-HPLC, method development, validation, LOD, LOQ.
Cite Article: "RP-HPLC method to Determination and Validation of Paroxetine Hydrochloride in Bulk and Pharmaceutical Dosage Form", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 10, page no.110 - 115, October-2022, Available :http://www.ijrti.org/papers/IJRTI2210018.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2210018
Registration ID:184291
Published In: Volume 7 Issue 10, October-2022
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Page No: 110 - 115
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2210018
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2210018
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ISSN: 2456-3315
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