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Acute promyelocytic leukemia (APL) is distinguished by the augmentation of promyelocytes in bone marrow. Nearly 95% of patients with this disease belong to typical APL, which express PML-RARA and and they exhibit magnificent clinical outcome. Compared to typical APL, variant APL showed quite different characteristics, and at present it is still challenged how to recognize, diagnose, and treat variant APL. Herein, we shared our clinical experiences about variant APL. By contrast, three regions of the PML locus are involved in the translocation breakpoints: intron 6 (bcr1; 55% of cases), exon 6 (bcr2; 5%), and intron 3 (bcr3; 40%). Through this article, we hoped to provide genetic perspective of variant APL.
Keywords:
Acute promylocytic leukemia, variant , leukemia
Cite Article:
"Molecular analysis of Acute promyelocytic leukemia and its variant fusion transcripts: A Hospital based study ", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 7, page no.1610 - 1612, July-2022, Available :http://www.ijrti.org/papers/IJRTI2207278.pdf
Downloads:
000204894
ISSN:
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator