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International Journal for Research Trends and Innovation
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
Issue per Year : 12
Volume Published : 10
Issue Published : 109
Article Submitted : 16128
Article Published : 7097
Total Authors : 19084
Total Reviewer : 688
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| Paper Title: | Biochemistry of Anticoagulant Drugs: A molecular approach |
| Authors Name: | Suryadeep Sur , Srijon Sen |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_182957
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| Published Paper Id: | IJRTI2207082 |
| Published In: | Volume 7 Issue 7, July-2022 |
| DOI: | |
| Abstract: | In this review we want to explore the underlying biochemistry of blood coagulation and mechanism of action of widely used anticoagulant drugs which function by targeting the components of biochemical machinery of coagulation pathway. After a compact summary of biochemical incidents involved in blood coagulation, structure-function relationship of drug targets of the various classes of drugs have been discussed. Action of vitamin K dependent inhibitors are responsible for the production of incomplete clotting factors, thus, impairing blood clotting. Synthesis of -carboxyl glutamic acid of GLA domain of factors is mediated by the vitamin K epoxide reductase which is inhibited by warfarin and other related molecules. Thrombin is the cardinal enzyme in blood coagulation process thus acting as a captivating drug target, PPACK and Argatroban are those drugs which inhibit the enzyme by covalent and non-covalent binding respectively. Another direct inhibitor of thrombin is hirudin, the anticoagulant weapon of leeches, recently being used in clinical treatments, binds in a bidental fashion with thrombin. The anticoagulant of human body, antithrombin is the drug target for the drug heparin which provides an augmented anticoagulant activity just by functioning as a bridge between thrombin and antithrombin. Pharmacokinetic features of the representative drugs of every class have also been discussed in this review. |
| Keywords: | anticoagulant, hemostatis, thrombomodulin, thrombosis, warfarin |
| Cite Article: | "Biochemistry of Anticoagulant Drugs: A molecular approach", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 7, page no.575 - 590, July-2022, Available :http://www.ijrti.org/papers/IJRTI2207082.pdf |
| Downloads: | 000204884 |
| ISSN: |
2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2207082
Registration ID:182957
Published In: Volume 7 Issue 7, July-2022
DOI (Digital Object Identifier):
Page No: 575 - 590 Country: Kharagpur, WEST BENGAL, India Research Area: Medical Science Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2207082 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2207082 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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