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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14
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| Paper Title: | An audit of cardioprotective natural products |
| Authors Name: | VIGNESH M , RAJESH M S |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJRTI_182752
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| Published Paper Id: | IJRTI2207040 |
| Published In: | Volume 7 Issue 7, July-2022 |
| DOI: | |
| Abstract: | Cardiovascular Diseases (CVDs) accounts for approximately 30% of overall death worldwide. There are various CVDs among which Myocardial Infarction (MI) and stroke are found to be the major contributor to mortality. Adrenaline and isoprenaline are the catecholamines used in various cardiovascular interventions. However, toxic doses causes stress on the myocardium causing necrosis in the cardiac muscles. It is discovered that pathophysiological and morphological alterations observed in these catecholamines overdose are similar to changes in MI in humans. Hence they are considered as reliable model to investigate protective effect in case of heart attack. Doxorubicin belongs to the class of anthracycline antibiotic, which is most widely used in the treatment of range of cancers such as leukaemias, lymphomas, sarcomas, solid tumors etc. Despite its widespread use it produces dose dependent selective cardiotoxicity via the formation of reactive oxygen species (ROS). Dexroxazone is the only approved drug by USFDA to alleviate DOX induced cardiotoxicity, the drawback is that it interferes with the clinical activity of DOX. Paradoxically, researchers investigated the potential of phytochemicals such as Curcuma longa, Allium sativum, Coleus forskohlii, Syzygium aromaticum, Crocus sativus etc. against drugs induced cardiotoxicity. Unlike synthetic drugs, phytochemicals from natural products are safe for long term use. The present article reviews possible mechanisms of inducing agents, changes in parameters and cardioprotective effects of various plant species against drugs induced cardiotoxicity. |
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| Cite Article: | "An audit of cardioprotective natural products ", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 7, page no.251 - 268, July-2022, Available :http://www.ijrti.org/papers/IJRTI2207040.pdf |
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2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID: IJRTI2207040
Registration ID:182752
Published In: Volume 7 Issue 7, July-2022
DOI (Digital Object Identifier):
Page No: 251 - 268 Country: Bengaluru, Karnataka, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2207040 Published Paper PDF: https://www.ijrti.org/papers/IJRTI2207040 |
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED,
Journal Starting Year (ESTD) : 2016
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