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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

Issue per Year : 12

Volume Published : 7

Issue Published : 74

Article Submitted : 3603

Article Published : 2063

Total Authors : 5474

Total Reviewer : 528

Total Countries : 39

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Paper Title: A Review on Development And Evaluation Of Mouth Dissolving Buccal Tablet For Antidiabetic Activity
Authors Name: Anjali Kumari , Brijesh Kumar Saroj , Rajan Chaudhary , Avanindra Kumar , Jai Prakash
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IJRTI_182263
Published Paper Id: IJRTI2206097
Published In: Volume 7 Issue 6, June-2022
DOI:
Abstract: Glimepiride is second generation new sulfonyl urea oral antidiabetic. Glimepiride is poorly soluble in acidic environment. The aim of this study was to design and optimize Glimepiride mucoadhesive buccal tablets for systemic delivery as an alternative route. Glimepiride containing mucoadhesive buccal tablets were developed by direct compression method. Four mucoadhesive polymers namely HPMC 100M, Xanthan gum, Chitosan and Guar gum were used for preparation of tablets which intended for prolong action. The prepared tablets were evaluated for different physical parameters and dissolution study was performed in pH 6.8 phosphate buffer solution for 12 hours. The compatibility study showed that the drug was compatible with polymers and other excipients. Tablet preformulation parameters were within the Pharmacopoeial limit. HPMC 100M showed above 95% release within 8 hours whereas HPMC 100M in combination with Gaur gum and Chitosan sustained the drug release over a period of 12 hours. The drug release from prepared tablets follows the Higuchi kinetic model, and the mechanism is found to be non-Fickian/anomalous according to Korsmeyer–Peppas model. The stability studies were carried out for 3 months and prepared tablets were found to be stable. Thus, the present study concluded that, Glimepiride buccal tablets containing combination of natural and synthetic polymer can be successfully prepared for the treatment of diabetes as well as for prolonged drug delivery. KEYWORDS: Glimepiride, Direct compression, Buccal tablets, HPMC 100M, Chitosan, Xanthan gum, Gaur gum, and Higuchi kinetic model.
Keywords: Glimepiride, Direct compression, Buccal tablets, HPMC 100M, Chitosan, Xanthan gum, Gaur gum, and Higuchi kinetic model.
Cite Article: "A Review on Development And Evaluation Of Mouth Dissolving Buccal Tablet For Antidiabetic Activity", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.7, Issue 6, page no.582 - 597, June-2022, Available :http://www.ijrti.org/papers/IJRTI2206097.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2206097
Registration ID:182263
Published In: Volume 7 Issue 6, June-2022
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Page No: 582 - 597
Country: Buxar, UP, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2206097
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2206097
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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