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International Journal for Research Trends and Innovation
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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

Issue per Year : 12

Volume Published : 7

Issue Published : 75

Article Submitted : 4301

Article Published : 2432

Total Authors : 6372

Total Reviewer : 533

Total Countries : 46

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Paper Title: A Review on Pulsatile Drug Delivery System
Authors Name: Rahath Bushra , Dr.Shahid Mohammed , Dr.A.Shajudha Begum
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Published Paper Id: IJRTI2007009
Published In: Volume 5 Issue 7, July-2020
Abstract: Traditionally, drugs are release in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are increasing developing interest. This framework is designed for chronopharmacotherapy which is based on circadian rhythm. The rationale for the empolyment of pulsatile release is for the drugs where a constant drug release ,i.e., a zero-order release is not desired. Pulsatile drug delivery system (PDDS) is defined as the rapid and transient release of certain amount of molecules within a short time period immediately after a predetermined off-release period, i.e., lag time. PDDS can be classified into time controlled systems wherein the dug release is controlled primarily by the delivery system; stimuli induced PDDS in which release is controlled by the stimuli, like the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. Therefore, Pulsatile drug delivery is one such system that, by delivering drug at the right time, right place and in right amount, holds good promises of benefit to the patients suffering from chronic problems like arthritis, asthma, peptic ulcer, cardiovascular diseases, and hypercholesterolemia. Current review article focuses on the necessity of pulsatile drug delivery systems, types of the disease in which pulsatile release is required, classification, evaluations, advantages, limitation, and future aspects of pulsatile drug delivery system.
Keywords: Pulsatile drug release, Chronopharmacotherapy, Circadian rhythm, Lag time, Time controlled systems.
Cite Article: "A Review on Pulsatile Drug Delivery System", International Journal of Science & Engineering Development Research (, ISSN:2455-2631, Vol.5, Issue 7, page no.67 - 78, July-2020, Available :
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2007009
Registration ID:181302
Published In: Volume 5 Issue 7, July-2020
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Page No: 67 - 78
Country: Hyderabad, Telangana, India
Research Area: Pharmacy
Publisher : IJ Publication
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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