REVIEW ON MICROSPONGE DRUG DELIVERY SYSTEM

Shereen Sultana , Dr. Shahid Mohammed

Microsponges, Controlled release, Target release, topical formulation, oral administration

Microsponges are at the forefront of the rapidly developing field of novel drug delivery technology. Microsponge drug delivery technology holds a great promise for reaching the goal of controlled and site-specific drug delivery and hence, has attracted wide attention of researchers. A Microsponges delivery system is a highly cross-linked, porous, polymeric microsphere, polymeric system consisting of porous microspheres that can entrap and release them into the skin over a long period of time. This delivery system provides extended release with reduced irrit ation, better tolerance, improved thermal, physical and chemical stability. The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Microsponge technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. In addition, numerous studies have confirmed that microsponge systems are non- irritating, non-mutagenic, on-allergenic, and non-toxic. Microsponge drug delivery system technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products. They are mostly used for topical use and have recently been used for oral administration. This article presents a broad review of Microsponges delivery system discussing the principles and preparation methods. Appropriate analytical techniques for characterization of Microsponges like Particle size and its distribution, surface morphology, porosity, density are covered. Advantages, limitations and their possible remedies of the microsponge drug delivery are also mentioned.

Volume 5 Issue 6, June-2020

Pages : 23 - 26