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ISSN Approved Journal No: 2456-3315 | Impact factor: 8.14 | ESTD Year: 2016
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Impact Factor : 8.14

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Paper Title: Method development and validation for the simultaneous estimation of Arterolane maleate and Piperaquine phosphate by HPLC in pharmaceutical dosage form( Tablet)
Authors Name: Sameer D. Pawar , Sayali Budhwant , Ketan Shinde , Ashwini Sable
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IJRTI_181232
Published Paper Id: IJRTI2004011
Published In: Volume 5 Issue 4, April-2020
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Abstract: A novel, precise, accurate, rapid and cost effective gradient high performance liquid chromatographic (HPLC) method was developed, optimized and validated for the estimation of Arterolane maleate and Piperaquine phosphate in pharmaceutical dosage forms (tablet). The drugs were estimated using JASCO C-18HS (250 mm x 4.6 mm i.d- 5 µm particle size) column. A mobile phase composed of phosphate buffer, methanol in proportion of 70:30 v/v, at a flow rate of 1.0 ml/min was used for the separation. Detection was carried out at 270 nm. The linearity range obtained was 5-30 µg/ml for ART and 10-60 µg/ml for PIP with retention times (Rt) of 3.735 min and 2. 839 min for ART and PIP respectively. The correlation coefficient values were found to be 0.999. Precession studies showed % RSD values less than 2 % for both the drugs in all the selected concentrations. The percentage recoveries of ART and PIP were in the range of 99.64-100.28% and 99.84-100.78% respectively. The assay results of ART and PIP were 99.63% and 99.81 % respectively. The limit of detection (LOD) and limit of quantification (LOQ) were 0.168 µg/ml 0.875 µg/ml for ART and 1.632 µg/ml and 2.741 µg/ml for PIP respectively. The method was validated as per the International Conference on Harmonization (ICH) guidelines. The proposed validated method was successfully used for the quantitative analysis of commercially available dosage form.
Keywords: Arterolane maleate, Piperaquine phosphate, HPLC, Validation
Cite Article: "Method development and validation for the simultaneous estimation of Arterolane maleate and Piperaquine phosphate by HPLC in pharmaceutical dosage form( Tablet)", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.5, Issue 4, page no.70 - 76, April-2020, Available :http://www.ijrti.org/papers/IJRTI2004011.pdf
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ISSN: 2456-3315 | IMPACT FACTOR: 8.14 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.14 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID: IJRTI2004011
Registration ID:181232
Published In: Volume 5 Issue 4, April-2020
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Page No: 70 - 76
Country: Wagholi, Maharashtra, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijrti.org/viewpaperforall?paper=IJRTI2004011
Published Paper PDF: https://www.ijrti.org/papers/IJRTI2004011
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ISSN: 2456-3315
Impact Factor: 8.14 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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