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Volume 3 | Issue 8

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Paper Title: SPECTROPHOTOMETRIC OXIDATION METHOD FOR THE DETERMINATION OF RISPERIDONE IN THE PRESENCE OF TRIHEXYPHENYDYL HCl BY USING BROMATE – BROMIDE MIXTURE AS AN OXIDANT
Authors Name: I. Lakshmi Prasanna , G.T. Naidu , Nuzhath Fathima , I.E.Chakravarthy , G. Abdul Huq
Unique Id: IJRTI1808006
Published In: Volume 3 Issue 8, August-2018
Abstract: A simple, sensitive, precise and accurate spectrophotometric method has been developed for the estimation of Risperidone in the presence of Trihexyphenydyl in pharmaceutical formulations and in the drug dosage form. During the study, it is observed that acidic solution of the drug formed the oxidation product with Bromate – Bromide mixture. This property of the drug is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed λmax at 320 nm. The linearity range for Risperidone in the presence of Trihexyphenydyl is found to be 10 μg/ml to 250 μg/ml. Recovery studies gave satisfactory results indicating that none of the common additives and excipients interfere in the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 0.9153×104 lit/ mole/cm and 0.0448 μg/ ml/ cm2 respectively.
Keywords: Spectrophotometry, Risperidone, Trihexyphenydyl HCl, Bromate-Bromide oxidant, Pharmaceutical formulations
Cite Article: "SPECTROPHOTOMETRIC OXIDATION METHOD FOR THE DETERMINATION OF RISPERIDONE IN THE PRESENCE OF TRIHEXYPHENYDYL HCl BY USING BROMATE – BROMIDE MIXTURE AS AN OXIDANT", International Journal of Science & Engineering Development Research (www.ijrti.org), ISSN:2455-2631, Vol.3, Issue 8, page no.28 - 32, August-2018, Available :http://www.ijrti.org/papers/IJRTI1808006.pdf
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Publication Details: Published Paper ID: IJRTI1808006
Registration ID:180396
Published In: Volume 3 Issue 8, August-2018
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ISSN Number: 2456 - 3315
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